Bianca Covington added 10 points for the Wildcats (13-4), who have now won five straight.
Two quick baskets early on by Jaquana Pauling and a three-pointer by Muhammad staked Johnson & Wales a quick 7-0 lead to start the game. Piedmont International cut the lead to five on an ensuing basket by Anaya Scott, but would never get any closer the rest of the way.
Vanderia Shackleford finished just shy of a double-double for Johnson & Wales, posting 12 rebounds and a season high eight assists.
Scott led Piedmont International on the evening with 14 points while Arian Rumph and Zyniah Kessler each finished with 10 points.
The Wildcats will resume play on Saturday when the team travels to Columbia, S.C., to play Columbia International University. Tip-off is scheduled for 1:00 p.m.